Health Impact News Editor Comments: Are those against genetically engineered foods “anti-science”? Peter Melchet answers this charge and shows how it is actually the pro-GM lobby that is against science. Be sure to also watch the short video below by Dr. Bernhoft, who discusses the lack of science behind genetically engineered food and how he has seen positive results from his patients who have chosen a GM-free diet.
The GM Lobby and its Seven Sins Against Science
By Peter Melchett
Soil Association
Excerpts:
Powerful forces in Western society have been promoting genetic engineering (now usually genetic modification – GM) in agricultural crops since the mid-1990s. They have included many governments, in particular those of the USA and UK, powerful individual politicians like George Bush and Tony Blair, scientific bodies like the UK’s Royal Society, research councils, successive UK Government chief scientists, many individual scientists, and companies selling GM products. They have ignored the views of citizens, and most sales of GM food have relied on secrecy – denying consumers information on what they are buying (20 US States are currently embroiled in fierce battles over GM labeling, strenuously opposed by Monsanto). Worse, they have consistently promoted GM in ways which are not only unscientific, but which have been positively damaging to the integrity of science.
This is, of course, an argument usually aimed at those who, like me, are opposed to GM crops. We are accused of being ‘anti-science’, emotional and irrational, and more recently, of being as bad as ‘Nazi book burners’ by the President of the National Farmers’ Union. This criticism has been effective in framing the debate about GM crops in the media in the UK, where the conflict over GM is routinely presented as a debate between those who are pro and those who are anti-science. This is reinforced by the fact that those selected to speak in favour of GM are usually themselves scientists (albeit often working for GM companies, or funded to work on GM crops), and those selected to oppose GM crops are usually environmentalists, farmers, or citizens concerned about the safety of the food they eat. Scientists who are critical of GM crops are almost never interviewed by the media.
This characterization of those opposed to GM as being anti-science has always ignored the fact that the NGOs concerned, like Greenpeace, Friends of the Earth and the Soil Association, are staunch supporters of science, have scientists working for them, and run campaigns to combat problems which were only identifiable through scientific investigation… People opposed to GM, including farmers and environmentalists, often have professional or scientific qualifications, and are well versed in the scientific disciplines that affect agriculture. This has not stopped supporters of GM crops dismissing all of these people as irrational, emotional, anti-science zealots.
Indeed, the basic science concerning the complexities of gene organization and function suggests that natural breeding, often augmented with the non-GM biotechnology tool of MAS, is a far more powerful and productive way forward for crop improvement. Natural breeding and MAS not only preserve gene order and function, but allow the multiple gene systems that confer desirable properties such as higher yield, pest-and blight-resistance, and tolerance to drought, salinity, and flood, to be rapidly and relatively inexpensively bred into crops – something which is still only a distant dream for GM crop technologists.
The fact that the framing of the debate about the use of GM technology in agriculture, between pro- and anti-science, has been successful does not make it correct. In fact, it is those who promote GM crops who have routinely abused science, ignored the basic principles of scientific investigation and proof, and ruthlessly attacked fellow scientists who disagreed with their pro-GM line. In doing so they have misused, abused and devalued science. If people have less respect for science than in the past, I hold the pro-GM lobby partly to blame. They have done real damage to the integrity and independence of science.
Here is the evidence on which I base this accusation.
The first sin
Pro-GM scientists have made the mistake of conflating their opponents’ opposition to commercial products (GM crops) with opposition to science. As I will show, those opposed to GM crops have a different, and I would say more accurate, understanding of the underlying science. But GM soya seeds are not ‘science’ – they are a commercial product.
These products have impacts in the real world. For example, they are used to alter the relationship between farmers and seed producers, preventing farmers saving their own seed. Once a GM variety has been grown, contamination makes it hard for the farmer to revert to non-GM crops, so GM crops tie farmers into long-term relationships with GM seed producers. This allows these companies to exert considerable power over the cost of farmers’ inputs (much as multiple retailers do over the price farmers receive for their outputs). It is now clear that existing GM crops have encouraged herbicide-resistant weeds and insecticide-resistant pests. This has led to ever higher use of more complex mixtures of pesticides to control these pests. As a result, the introduction of most GM crops leads to large increases in pesticide use, rather than the decreases predicted by the GM industry.
The GM traits can be passed by crossing to wild relatives of the crop, and the insecticide in GM Bt crops can destroy beneficial soil fungi. GM crops have negative environmental impacts, as the UK Government’s scientific research programme (the Farm Scale Evaluations), which I opposed, showed.
To oppose GM crops for all or any of these reasons is not ‘anti-science’. On the contrary, opponents of GM use scientific evidence and cite the practical consequences of growing GM crops as arguments against the use of this particular agricultural technology.
The second sin
Proponents of GM made the mistake of assuming that the scientific breakthrough of unraveling DNA structure and function, and the discovery of DNA-manipulating enzymes (which led to the development of genetic engineering technology being applied to crops), was based on a full understanding of how genes work. As the history of science shows, many great scientific breakthroughs initially appear to have solved some long-standing problem. But on further investigation, it is frequently the case that the new breakthrough raises a host of new questions and areas for investigation. Those of us who love science find this one of the fascinating things about it.
But the companies that were developing GM crops based their ideas on an over-simplistic model of the control of gene expression, and convinced themselves that they were dealing with a straightforward process – hence their initial decision to call the technology of altering crops ‘genetic engineering’. They believed that each gene had a single, unique, independent function, and that moving a gene from one plant or animal to another would allow that gene to express that particular function wherever and however it was located.
Even back in the mid-1990s, some scientists said that pro-GM geneticists were oversimplifying gene expression. They pointed out that the geneticists were ignoring relationships that genes have with other genes and relationships that groups of genes have with other groups elsewhere in an organism’s DNA. They pointed out too that the geneticists were ignoring the other factors that effect the regulation of gene expression.
We now know that these scientists were right, and that gene expression is more complex than was initially supposed. Gene organisation within the genome is not random. Genes tend to be grouped into coordinated functional units, and control of expression is far more complex than was initially supposed. The emerging science of epigenetics has demonstrated that, for example, mice with identical DNA can turn out to have extreme variations, between disease-prone, obese animals and fit, slim animals, simply because of the impact that dietary inputs and environmental chemical exposures have on their DNA control mechanisms during pregnancy. Much of the scientific case for GM crop technology is based on a grossly over-simplified view – that genes work as isolated units of information – which we now know to be wrong.
One consequence of the disruptive effect of the GM transformation process is that it can negatively affect crop performance (for example ‘yield drag’ seen with GM soya). Another consequence is the production of novel toxins and allergens, as well as disrupted nutritive value.
The third sin
Instead of embracing new scientific discoveries in this area, the many scientists involved in promoting GM technology have found a number of ways of trying to disguise or ignore the fact that the processes they are promoting are much more complex than they claim.
For example, transferring genes (usually at random) from one plant to another is a far more uncertain, unstable and disruptive process than was originally thought. In order to avoid the costly and time-consuming safety testing of foods produced through this new technology, the Organisation for Economic Cooperation and Development (OECD) – a body devoted not to public health but to facilitating international trade – came up with the concept of ‘substantial equivalence’. This assumes that if relatively simplistic chemical analyses of, say, a GM sweetcorn’s protein, carbohydrates, vitamins and minerals, find values that can also be found within the range of non-GM sweetcorn varieties, then the GM sweetcorn is deemed to be indistinguishable from, and therefore as safe as, non-GM sweetcorn.
Substantial equivalence was used to deny the need for any biological or toxicological safety testing of GM foods, because GM food was now assumed to be the same as the equivalent food that people had been eating for hundreds of years. This was a political and commercial decision, taken in consultation with, and on behalf of, a small number of large GM companies. It had nothing to do with science. We now know it was opposed by some scientists in the US Federal Drug Administration (FDA), but it was pushed through by political appointees to the FDA. The same approach has spread to many other countries, although some are now less enthusiastic, and the European Union avoids using the term “substantial equivalence”, redefining it as the “comparative assessment” process. However, proponents of the European concept of “comparative assessment” admit that it has much the same meaning as “substantial equivalence”.
An increasing number of detailed biological tests comparing GM and equivalent non-GM crops have now been carried out, not just looking at gross values but rather the spectrum of different types of proteins and other biochemical components. These studies, though few in number, clearly show major differences between the GM and non-GM plants, demonstrating that they are not substantially equivalent. This science invalidates the use of substantial equivalence to assess the safety of GM crops and food, but it is still used in the USA and forms the basis of safety assessments of GM crops in Europe.
There is still no requirement, in any country in the world, for GM food to be tested in long-term or lifetime animal feeding trials. Nor is there any requirement to test GM food by feeding it to several generations of mice or rats, to see whether it has any identifiable impact. So there is no regulatory requirement for GM food to be tested to see whether it is safe for humans to eat.
In response, it is claimed that much non-GM plant breeding involves chemical or radiological mutagenesis, and thus gives rise to the same risks as GM crop breeding, so it would be wrong to apply extra controls on GM crops and food. It is true that chemical and radiation-induced mutation crop breeding is highly mutagenic. But there is a good reason why it is not widely used – it produces a large proportion of unhealthy and deformed plants. In fact, some scientists have called for plants produced by mutation breeding to be tested in the same way as GM crops.
In addition, there is the possibility that there are features of the GM process itself that may affect the genome that are not possible in non-GM crop breeding. And GM allows a gene to be inserted in radically different foodstuffs. For example, in the case of allergic reactions, affected individuals could no longer simply avoid foods they know they are allergic to, as GM crop breeding could allow a toxic, allergenic or sensitising protein to be inserted in any food, with no warning labels.
The fourth sin
While one result of the adoption of the US interpretation of the unscientific concept of ‘substantial equivalence’ was to discourage scientific studies of the impact of eating GM foods, in practice, the GM companies try to make sure that studies cannot be conducted at all by independent scientists. As an editorial in Scientific American in August 2009 said:
“It is impossible to verify that genetically modified crops perform as advertised. That is because agritech companies have given themselves veto power over the work of independent researchers…. Research on genetically modified seeds is still published, of course. But only studies that the seed companies have approved ever see the light of a peer-reviewed journal. In a number of cases, experiments that had the implicit go-ahead from the seed company were later blocked from publication because the results were not flattering…. It would be chilling enough if any other type of company were able to prevent independent researchers from testing its wares and reporting what they find.… But when scientists are prevented from examining the raw ingredients in our nation’s food supply or from testing the plant material that covers a large portion of the country’s agricultural land, the restrictions on free inquiry become dangerous.”
One of the consequences of this determination to stop science working when it comes to research on GM crops, is that numerous pro-GM scientists have fallen into the unscientific trap of claiming that, because GM food has now been eaten by millions of people for several years, it is clearly ‘safe’. As most GM food has been eaten in the USA, and in the period since GM food has been produced, the US has suffered a catastrophic increase in diet-related ill health, these same scientists might as well claim that GM food is extraordinarily damaging to human health. Because there has been no GM food labeling in the US, no post-market monitoring, and no epidemiological research, we simply don’t know. But to claim that the absence of evidence of harm from GM food means that there is evidence that GM food is safe, when none of the necessary research has been done, shows a willful disregard for basic scientific principles.
The fifth sin
Although proper studies are difficult to carry out because of the problems of obtaining samples of GM material, some studies have been done looking at the impact of GM diets on animals. Worryingly, these studies, conducted by independent scientists, show negative health effects.
The first and best known of these studies was carried out in Scotland by Dr. Arpad Pusztai. His study, and others that have been conducted since, suggest that some adverse impact was being caused to multiple organ systems in the test animals. None of these studies can claim to be conclusive, and most have not been well funded, but they show evidence of potential harm that the scientists involved say needs to be further investigated. All the scientists have been viciously attacked by pro-GM scientists.
Re-evaluations by independent scientists of data obtained from the GM crop industry’s own animal feeding studies also demonstrate clear signs of toxicity. The organs consistently affected are the liver and kidney, the two major detoxification organs, with ill effects on the heart, adrenal glands, spleen, and blood cells also being observed.
What is needed are long-term and lifetime animal feeding studies to see the effects of eating GM foods over an extended period – reflecting the real-life exposure of humans. In addition, multigenerational studies are needed to see the effects on reproduction and future generations. Such studies are compulsory for pesticides and pharmaceutical drugs, but not for GM foods – even though the exposure is likely to be longer-term for a food than for a pesticide or drug.
One of the great things about science is that, in theory at least, it should not be subject to the whims of those in power or those with money. Anyone making a claim on the basis of scientific evidence should publish their evidence in a form that will allow any other scientist to repeat their experiment, and show whether they are right or wrong. Some of the richest and most powerful organizations in the world attacked Dr. Pusztai and his work, particularly the UK’s Royal Society. However, to their shame, not one of these critics has seen fit to do what any student learning about scientific method would be told should be the first step, namely, to repeat the experiment. An experiment can be repeated with any modifications that would, in the eyes of the critic, make the study acceptable.
Work done by a young Russian scientist, and by Austrian scientists, has been attacked in exactly the same way, and no effort has been made to repeat those experiments in order to justify these attacks. These personal attacks have sometimes been coupled with threats that the scientists might lose their jobs or funding (as indeed Dr. Pusztai did). But not once anywhere in the world has a pro-GM scientific body or GM company responded to a scientific study they do not like, by doing what anyone who cared about science should do – repeating the experiment.
The sixth sin
One response to these criticisms from the pro-GM scientists is to claim that there is in fact a rigorous, scientific, regulatory regime, for example in the USA and EU, which proves that GM crops are safe. The regulatory regime for GM crops is not based on science, but rather on selected information from GM companies. And because of the perceived need for commercial confidentiality, not all the research the companies give to the regulators is published.
The gold standard of science is peer reviewed, published research. Open publication is fundamental to the integrity of science, and a prerequisite to another key principle on which science rests, namely the fact that conclusions can always be tested by repeating the research. In the area of GM crops, as in some others, what is claimed to be ‘scientific’ regulation is based on a perversion of science – secretive and (because there is no requirement to publish or even list all studies) possibly highly selective, corporate information.
Independent researchers and NGOs like Greenpeace have used court orders (under EU Freedom of Information laws) to obtain access to previously secret corporate studies. Re-evaluation of the industry raw data shows that the scientists involved selectively studied only a few questions, and interpreted what little evidence they had in ways that favoured corporate interests. Major flaws in the experimental design were evident, which served to mask rather than reveal the effects of the GM transformation process. Nevertheless, these short, 90-day rat feeding studies did show clear signs of toxicity arising from the GM compared to non-GM equivalent feed. If such signs of toxicity are evident after just 90 days, then clearly, lifelong (2-year) studies are urgently needed.
The seventh sin
Almost all the claims made for GM crops by proponents of the technology are claims about benefits that GM technology will deliver in future. This is not a new phenomenon – such claims were being made in the late 1990s, when GM crops were first introduced. Claims that GM crops will solve world hunger, or will deliver drought resistant, nitrogen-fixing or nutrient rich crops, are not science but prophecy.
The pro-GM lobby and the media treat these claims as if they are science, but none of them are based on scientific evidence. They are opinions, not science, often expressed by companies or scientists with a strong financial interest in seeing them treated as fact.
Summary
When the history of the changes in the public understanding of science and public confidence in science over the last fifteen years comes to be written, I believe that the pro-GM lobby’s misuse and abuse of science will be seen to have had a chilling impact. These people, organizations and companies have been responsible for part at least of the sad decline in both public understanding and confidence in science and scientific evidence.
Peter Melchett is Policy Director at the Soil Association.
Read the full article, along with all 91 references here: http://www.soilassociation.org/motherearth/viewarticle/articleid/4752/the-pro-gm-lobbys-seven-sins-against-science
Dr. Robin Bernhoft is a fellow and past president of the American Academy of Environmental Medicine and director of the Bernhoft Center for Advanced Medicine in Ojai California. Dr. Bernhoft, MD, was born in Fargo, North Dakota, graduated cum laude from Harvard College and earned his MD at Washington University Medical School, St Louis. After surgery residency at UCSF, where he published over twenty scientific papers, and a liver/pancreatic surgery fellowship in London, England, he entered private practice in the Seattle area, joining the clinical faculty of the University of Washington Medical School. After several years of busy surgical practice, he became environmentally ill, from leaving disinfectant on his hands throughout 600 operations per year. The toxic chemicals he absorbed swamped his ability to detoxify, and gave him skin, respiratory and GI problems which caused him to lose 35 pounds in four months. In order to understand what was happening to him, and to survive, Dr Bernhoft retrained in environmental medicine, 2002-6. By applying what he learned, he regained his health, and shed his sensitivity to perfumes and mold.Dr Bernhoft is now able to run 20 to 30 miles per week, and is three belts short of black belt in Shito Ryu karate. He has his life back, and is eager to use what he has learned to help others regain theirs.
In this video Dr. Bernhoft discusses the various health impacts of genetically-modified food, and the lack of science supporting GM foods.
Learn more about Dr. Bernhoft here: http://drbernhoft.com/