July 22, 2014

Using the High Fat Ketogenic Diet to Heal Brain Tumors

pin it button Using the High Fat Ketogenic Diet to Heal Brain Tumors

brian tumor growth Using the High Fat Ketogenic Diet to Heal Brain Tumors

glucose accelerates brain tumor growth

Health Impact News Editor Comments:

Some of the most exciting research regarding the ketogenic diet has been in its use against cancer. This research is showing that a high-fat low-carbohydrate diet can starve cancer cells. We published several stories on the ketogenic diet and cancer in 2013.

In this study conducted at the University of Pittsburgh Medical Center, the ketogenic diet was used successfully to treat brain tumors.

The Restricted Ketogenic Diet: An Alternative Treatment Strategy for Glioblastoma Multiforme

a report by Thomas N. Seyfried, Purna Mukherjee, Miriam Kalamian and Giulio Zuccoli

Biology Department, Boston College; Dietary Therapies, LLC, Hamilton;  Radiology Department University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh, Pittsburgh

Excerpts:

Glioblastoma multiforme (GBM) is considered the most malignant of primary brain cancers with only about 12% of patients living beyond 36 months (long-term survivors).

Ketogenic Diet and Calorie Restriction

The high fat, low carbohydrate ketogenic diet (KD) has long been recognized as an effective non-toxic therapy for reducing epileptic seizures in children. The mechanisms by which the KD manages seizures are linked to shifts in brain energy metabolism. Glucose is the sole metabolic fuel used for nearly all brain functions under normal physiological conditions, but the brain will metabolize ketone bodies for energy when access to glucose is limited, as would occur during water-only therapeutic fasting in humans or during calorie restriction in mice.  It has long been known that water-only fasting or calorie restriction is effective in managing epilepsy in humans and mice.

The KD was introduced as an alternative to fasting for the long-term management of seizures in humans. The efficacy of the classic KD is optimal when the ratio of dietary fats to combined carbohydrate/protein is 4:1. This requires careful attention to diet calculations. Importantly, the KD is also gaining recognition as a potential therapy for a host of other neurological and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, and stroke. When administered in restricted amounts, which do not exceed the individual’s total energy needs, the KD can also be therapeutic against malignant brain tumors in mice and humans.

Evidence from Case Reports

In 1995, Nebeling and coworkers attempted the first nutritional metabolic therapy for human malignant brain cancer using the ketogenic diet. The objective of the study was to shift the prime substrate for energy  metabolism from glucose to ketone bodies in order to disrupt tumor metabolism while maintaining the nutritional status of patients. The patients in this landmark clinical study included two female children with nonresectable advanced stage brain tumors (anaplastic astrocytoma stage IV, and cerebellar astrocytoma stage III). Measurable tumor remained in both subjects following extensive radiation and chemotherapy. Although severe life threatening adverse effects occurred from the radiation and chemotherapy, both children responded remarkably well to the KD and experienced long-term tumor management without further chemo or radiation therapy. Indeed, one of the patients remains alive at the time of this writing (Nebeling, personal communication). Positron Emission Tomography with fluro-deoxy-glucose (FDG-PET) also showed a 21.8% reduction in glucose uptake at the tumor site in both subjects on the KD. These findings indicate that a ketogenic diet, which lowers glucose and elevates ketone bodies, could reduce glycolytic energy metabolism in these brain tumors.

Despite the documented efficacy of the RKD as a non-toxic metabolic therapy for brain cancer in case reports, no major clinical trials of this therapy have been initiated in the US to date. A clinical trial using the unrestricted KD for recurrent glioblastoma has been initiated in Germany (ERGO Trial) under the direction of J. Rieger at the University of Tübingen. Modest improvement was reported without adverse effects, but no published information is yet available on blood glucose or blood ketone levels in the treated patients. This information will be needed to gauge the degree of energy stress on surviving tumor cells, as blood glucose levels are predictive of therapeutic efficacy. Careful documentation of blood glucose and ketone levels will be essential for predicting therapeutic efficacy.

The reason for not initiating clinical trials on the RKD for brain cancer management in the US remains unclear. Some have suggested that the North America Brain Tumor Collaborative (NABTC) prefers “hand-medown” drug therapies from other cancer studies rather than exploring potentially more effective alternative approaches. It is unknown if the reluctance to consider alternative approaches to GBM management rests with the NABTC or with those who advise the Collaborative. Based on pre-clinical studies in mice and case studies in patients, it is obvious that the RKD should be investigated for its therapeutic potential for managing GBM and other malignant brain cancers. The failure to initiate clinical trials is unfortunate especially for those GBM patients who might benefit from using the RKD for managing their disease.

Read the Full Study Here.

See Also: Gluten-free Ketogenic Diet with MCTs Reverses Autism and Eliminates Seizures

cancer the forbidden cures DVD Using the High Fat Ketogenic Diet to Heal Brain Tumors

Purchase the DVD – Free Shipping Available! Click image to view the trailer.

0 commentsback to post

Other articlesgo to homepage

Black Cumin Seeds Better Than Drugs? A Look at  the Science

Black Cumin Seeds Better Than Drugs? A Look at the Science

Black cumin seeds and black cumin seed oil have been widely used for reducing blood pressure, cleansing and tonifying the liver, reducing fluid retention, supporting healthy digestion, treating diarrhea, stimulating the appetite, reducing pain, and treating skin disorders. Studies have confirmed numerous pharmacological benefits. Black cumin seeds are also called Nigella sativa seeds. These seeds have anti-diabetic and anti-cancer properties. They can be used to regulate the immune system, reduce pain, kill microorganisms, reduce inflammation, inhibit spasmodic activity, and open the tiny air passages in the lungs. Black seed oil protects the liver, the kidneys, and the stomach/ digestive system. It is a powerful antioxidant.

Children Raised on Small Dairy Farms Develop 90% Fewer Allergies

Children Raised on Small Dairy Farms Develop 90% Fewer Allergies

A new study published in Sweden shows that children who live on small dairy farms run one-tenth the risk of developing allergies as other children. This study confirms the same results observed among small Amish dairy farms last year, where the drinking of farm-fresh raw milk was shown to be a cure for many allergies. The authors of the study suspect that the development of a healthy gut flora, as a result from living on the farm and being exposed to many different types of bacteria, is a major factor in developing immunity to allergies.

How Chili Peppers Can Be Used to Treat Pain

How Chili Peppers Can Be Used to Treat Pain

Chili peppers’ heat comes from capsaicin, a compound produced to protect them from fungal attack.

Capsaicin is available in pain-relieving creams and patches, and has shown promise for relieving shingles pain, osteoarthritis, psoriasis symptoms, and more.

Capsaicin has both antioxidant and anti-inflammatory properties, and has also shown some promise for cancer, weight loss, and allergy symptoms.

Study: Rosemary Herb Reduces Cognitive Decline in Elderly

Study: Rosemary Herb Reduces Cognitive Decline in Elderly

‘Rosemary Is For Remembrance’ ~ Science Confirms Wisdom of the Ancients By Sayer Ji GreenMedInfo.com “There’s rosemary, that’s for remembrance…” ~ William Shakespeare Since ancient times, herbs have been appreciated for their profound therapeutic effects.Science as a form of evidence-gathering did not take the epistemological pole position until quite recently in cultural history, with the

Should We All Soon Stop Bathing And Instead Use Probiotics for the Skin?

Should We All Soon Stop Bathing And Instead Use Probiotics for the Skin?

Will human beings soon stop bathing and instead use pro-biotics for the skin? Meanwhile, must we try to kill every germ on us, good or bad, with triclosan?

read more


Get the news right in your inbox!