hpv vaccination
Mass HPV Vaccination Plan for the U.S.
by Kate Raines and Barbara Loe Fisher
The Vaccine Reaction
The American Cancer Society (ACS) has set an aggressive goal to achieve an 80 percent uptake rate among American children with two doses human papillomavirus (HPV) vaccine by 2026.
To gain that coverage, 14 million more preteen children would need to complete the two-dose series, for a total of 57.62 million doses above and beyond the number of vaccinations given to date.1
HPV vaccine is one of the most expensive vaccines on the CDC recommended childhood vaccine schedule, costing a pricey $168 to $204 per dose, with Merck being the sole producer of HPV vaccine (Gardasil) in the U.S.2
The rationale ACS has given for setting the 80 percent HPV vaccine coverage goal is based on the number of reported cancers and cancer deaths associated with chronic HPV infection in the United States.
The Centers for Disease Control (CDC) estimates that about 42,700 (24,400 in women and 18,300 in men) are diagnosed with an HPV-related cancer annually.3
HPV is believed to be responsible for 63 to 91 percent of cervical, anal, vaginal, oropharyngeal, vulvar and penile cancers.
According to the CDC, invasive cancers are not generally tested for the presence of HPV in most cancer registries, so data are estimated based on the finding of HPV DNA in special studies used a reference for reference for making estimates.4
Until the last few years, cervical cancer was the predominant type associated with chronic HPV infection, but between 1999 and 2015 oropharyngeal cancer began increasing rapidly and has now overtaken cervical cancer as the most common cancer linked to HPV.4
Rates of cervical and vaginal carcinoma have continued a downward trend seen since pap screening became a routine part of women’s health care beginning in the late 1950s.1
The ACS estimates that in 2018, the U.S. will have a total of:
- 13,240 diagnoses of invasive cervical cancer, with 4,170 deaths
- 51,540 diagnoses of oral cavity or oropharyngeal cancer, with 10,030 deaths
- 5,170 diagnoses of vaginal cancer, with 1,330 deaths
- 2,320 diagnoses of penile cancer, with 380 deaths
- 8,580 diagnoses of anal cancer (5,620 in women and 2,960 in men), with 1,160 deaths (680 in women and 480 in men)
- 6,190 diagnoses of vulva cancer, with 1,200 deaths.5
These six potentially HPV-related cancers add up to approximately 18,000 deaths annually, accounting for less than three per cent of the 595,000 reported annual U.S. cancer deaths.4
Of note is the fact that, in 2005, a year before the first four-strain HPV vaccine, Gardasil, was licensed and recommended for all 12-13 year old girls, the American Cancer Society estimated that there were 10,370 cervical cancer cases with 3,710 deaths.6
Compared to the estimated 13,240 cervical cancer cases and 4,170 deaths in 2018, this represents an increase in cervical cancer cases in the U.S. after a decade of HPV vaccine use among adolescents.
The CDC reported that by 2017, 71 percent of adolescent girls had received more than one dose of HPV vaccine and there was a 68 percent coverage rate among all adolescents.7
HPV Infection Common and Usually Benign
Almost everyone who has been sexually active will contract an asymptomatic HPV infection at some point, but in almost all cases, the body clears the virus on its own within two years without complications.
Even when vaginal or cervical HPV infection does not resolve spontaneously and becomes chronic, it often “takes decades to progress to invasive cervical cancer.”4
HPV Vaccination Program Raising Red Flags
Since its introduction in June 2006, Merck & Co.’s HPV vaccine Gardasil has been embroiled in controversy. Originally, concerns were raised that perceived protection against a sexually transmitted virus might encourage young girls to engage in sexual activity, although no evidence has emerged to show that is the case.6
There also have been concerns that the pre- and post-licensure safety studies of the fast-tracked Gardasil vaccine were both overstated and misleading, with reported results selectively chosen to increase the appearance of positive results.8
The Food and Drug Administration (FDA) allowed Merck to use an aluminum containing placebo as a control in safety studies, even though Gardasil contains an aluminum adjuvant, effectively increasing the appearance of safety.9
Immediately after Gardasil vaccine was licensed in 2006, Gardasil’s potential for causing serious side effects began to be seen, as has been widely reported.10
The serious complications of HPV vaccination continue to be reported today in countries around the world.11
Although U.S. health officials have continued to deny a causal connection, Japanese researchers have pointed out that the temporal association with post- Gardasil clinical symptoms such as “chronic regional pain syndrome, orthostatic intolerance, and/or cognitive dysfunction” suggests a causal relationship with the vaccine.13
Other health issues associated with HPV vaccination include nervous and immune system disorders such as postural orthostatic tachycardia syndrome (POTS), chronic fatigue syndrome, blood clots, acute respiratory failure and cardiac arrest.
Also widely reported are menstrual abnormalities and premature ovarian failure.14
Using the MedAlerts search engine, as of April 30, 2018, the federal Vaccine Adverse Events Reporting System (VAERS) contained more than 58,992 reports of HPV vaccine reactions, hospitalizations, injuries and deaths including 430 related deaths, 794 hospitalizations, and 2,773 disabling conditions.
Over 45 percent of the reported serious adverse events occurred in children and teens 12-17 years of age.15
Too Soon to Claim Cancer Prevention
Contrary to the popular assertion that HPV vaccination “prevents cervical cancer,”16 the vaccine is too new for any real data on the effect it might have on incidence of cancer.
All that can realistically be measured is the reported incidence of HPV infections associated with the nine HPV strains included in a newer version of Merck’s Gardasil vaccine that was licensed in 2015.17
Research has shown that women vaccinated with Gardasil have a higher incidence of HPV infection with HPV strains that are not covered by the vaccine.14
One meta-analysis indicated a slight increase in two “nonvaccine high-risk HPV types (HPV39 and HPV52) and in two possible high-risk types (HPV53 and HPV73).”18
Those researchers said that, although the results merit further study, they were not conclusive at this point.
With current technology and routine medical check-ups and screening, chronic HPV infection is often detectable and manageable. The available evidence does not support an aggressive plan to spend more than $11 billion to pursue an 80 percent vaccination rate among children with an under-studied and highly reactive vaccine to theoretically prevent less than three percent of all cancers in the US.
Read the full article at TheVaccineReaction.org.
Comment on this article at VaccineImpact.com.
More information about Gardasil
Illinois Teen Dies Three Weeks After Being Injected with HPV Gardasil Vaccine
California Nurse Gives Gardasil Vaccine to Own Daughter who Develops Leukemia and Dies
Infant Accidentally Vaccinated with Gardasil – Mother Blamed for Vaccine Injuries and Baby Medically Kidnapped
The Happy-go-Lucky Girl I had Pre-HPV Vaccine is Gone Forever
Iowa Girl Faces Death: Life Destroyed by Gardasil Vaccine
Gardasil Vaccine Given without Consent and Ruins Life of 14 Year Old Girl
After 3 Years of Suffering 19 Year Old Girl Dies from Gardasil Vaccine Injuries
Gardasil: The Decision We Will Always Regret
15 Year Old French Girl’s “Descent into Hell” After Gardasil Vaccine – Wheelchair Bound and Paralyzed
The Gardasil Vaccine After-Life: My Daughter is a Shadow of Her Former Self
Gardasil: An Experience no Child Should Have to Go Through
I Want my Daughter’s Life Back the Way it was Before Gardasil
Gardasil Vaccine: Destroyed and Abandoned
15-Year-Old Vaccinated by Force with Gardasil now Suffers from Paralysis and Pain
Recovering from my Gardasil Vaccine Nightmare
Gardasil: We Thought It Was The Right Choice
“HPV Vaccine Has Done This to My Child”
13 Year Old World Championship Karate Student Forced to Quit After Gardasil Vaccine
If I Could Turn Back Time, Korey Would not Have Received any Gardasil Shots
What Doctors Don’t Tell You: Our Gardasil Horror Story
Family Fights U.S. Government over Compensation for Gardasil Vaccine Injuries
Gardasil: When Will our Nightmare End?
HPV Vaccine Injuries: “I Cannot Begin to Describe What it is Like to Watch your Daughter Live in Such Agony”
Gardasil: Don’t Let Your Child Become “One Less”
The Gardasil Vaccine Changed Our Definition of “Normal”
Gardasil: I Should Have Researched First
“They’ve Been Robbed of Their Womanhood” – Local Milwaukee Media Covers Gardasil Vaccine Injuries
Gardasil: The Day Our Daughter’s Life Changed
Gardasil: The Decision I will Always Regret
Gardasil Vaccine: One More Girl Dead
Gardasil: A Parent’s Worst Nightmare
After Gardasil: I Simply Want my Healthy Daughter Back
Gardasil: My Family Suffers with Me
Gardasil Changed my Health, my Life, and Family’s Lives Forever
Gardasil: Ashlie’s Near-Death Experience
Gardasil: My Daughter’s Worst Nightmare
My Personal Battle After the Gardasil Vaccine
Gardasil: The Worst Thing That Ever Happened to Me
A Ruined Life from Gardasil
HPV Vaccines: My Journey Through Gardasil Injuries
The Dark Side of Gardasil – A Nightmare that Became Real
Toddler Wrongly Injected with Gardasil Vaccine Develops Rare Form of Leukaemia
References:
1 Hackett DW. 57 Million HPV Vaccine Doses Needed by 2026. Precision Vaccinations. Oct. 2, 2018.
2 Centers for Disease Control and Prevention. Vaccine Price List. Nov. 1, 2018.
3 Centers for Disease Control and Prevention. United States Cancer Statistics. Data Brief. CDC.gov August 2018.
4 CDC. Trends in Human Papillomavirus–Associated Cancers — United States, 1999–2015. CDC.gov Aug. 24, 2018.
5 National Vaccine Information Center. Can HPV Cause Injury and Death? NVIC.org Vaccines and Diseases 2018.
6 Jemal A, Murray T et al. Cancer Statistics, 2005. CA: A Cancer Journal for Clinicians 2005; 55(1): 10-30.
7 CDC. National, Regional and Selected Local Area Vaccine Coverage Among Adolescents Aged 13-17 Years – United States, 2017. MMWR Aug. 24, 2018.; 67(33): 909-917.
8 Jenco M. Study: HPV vaccine legislation not linked to increase in risky sexual activity. AAP News Aug. 13, 2018.
9 Tomljenovic L, et al. Human Papillomavirus (HPV) Vaccines as an Option for Preventing Cervical Malignancies: (How) Effective and Safe? Cur Pharm Des 2013.
10 Debold V, Fisher BL. Human Papilloma Virus Vaccine Safety Analysis of Vaccine Adverse Events Reporting System (VAERS) Reports Part 1: Adverse Reactions, Concerns and Implications. National Vaccine Information Center Feb. 1, 2007.
11 Holland M, Rosenberg CM, Iorio E. The HPV 12 NVIC. Merck’s Gardasil Vaccine Not Proven Safe for Little Girls. NVIC.org June 27, 2006.
13 Ozawa K et al. Suspected Adverse Effects After Human Papillomavirus Vaccination: A Temporal Relationship Between Vaccine Administration and the Appearance of Symptoms in Japan. Drug Saf July 25, 2017.
14 Mercola J. HPV Vaccine Risks You Should Know About. Mercola.com 2018.
15 NVIC. Human Papillomavirus (HPV) & HPV Vaccine Quick Facts. NVIC.org.
16 Scutti S. HPV Vaccines Prevent Cervical Cancer, Global Review Confirms. CNN May 8, 2018.
17 American Cancer Society. FDA Approves Gardasil 9 HPV Vaccine. Cancer.org Jan. 8, 2015.
18 Mesher D, et al. Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes. Emerg Infect Dis October 2016.
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