October 2, 2014

Anti-depressants Can Cause Sudden Death

pin it button Anti depressants Can Cause Sudden Death

Doctor With Pills 300x200 Anti depressants Can Cause Sudden Death

Most antidepressants cause a change in the electrical pulse of the heart, which changes the rhythm of the heart beat. It’s called an extended QT interval—and it can result in sudden death with no warning of any kind: BMJ study.

by Heidi Stevenson
Gaia Health

The antidepressant citalopram—brand names Celexa and Cipramil—has joined a growing list of drugs that can cause sudden death by stopping the heart. The study, published in the BMJ[1], found that the drug causes lengthening in the QT interval, a part of the heart beat cycle.

Several drugs are noted for this issue. The most famous is methadone, noted for sudden death in some individuals, especially when dosage is increased too rapidly. There are no symptoms indicating a risk. A perfectly normal person will literally drop dead.

The heart beat is regulated by electrical pulses. Certain points of the wave pattern that’s printed out for an electrocardiogram (ECG) are labeled Q, R, S, and T, as illustrated in the graphic to the right.

If the time between Q and T is lengthened, it’s referred to as extended, elongated, or long QT syndrome, or QT interval prolongation. The only way to know if it’s happening is through an ECG.There are generally no external clues, so outside of testing, you would have no way of knowing that you’ve been affected.

The Study

The study’s authors are quite specific about the risk associated with Celexa. The larger the dose, the greater the risk. They noted that the FDA has said:

Citalopram causes dose-dependent QT interval prolongation. Citalopram should no longer be prescribed at doses greater than 40 mg per day.

A quick look at Medscape’s drug reference for citalopram confirms that statement[2].

The researchers examined 38,397 adults who were taking either an antidepressant or methadone at some point between February 1990 and August 2011, more than two decades. The antidepressants that subjects took were citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline, bupropion (Zyban), duloxetine (Cymbalta), mirtazapine (Remeron), nortriptyline, and venlafaxine (Effexor).

All study participants received an electrocardiogram (ECG) 14-90 days after they’d taken their prescribed drug. The study found that all antidepressants affect the QT interval to some degree, though methadone was worse by a significant amount.

Interestingly, bupropion (Zyban), had the opposite result of the other drugs. The QT interval was shortened. That, though, doesn’t make it safe, as a shorter QT interval can cause palpitations and fainting, and can also result in sudden cardiac arrest.

The worst of the antidepressants for lengthening the QT interval were citalopram (Celexa), escitalopram (Lexapro), and amitriptyline. However, overall, one in five people taking these drugs experienced abnormal ECGs with extended QT intervals. The authors state that the clinical significance of these findings is unknown.

We do know that an extended QT interval can result in sudden death. In reality, this doesn’t happen often—though no one can quantify the frequency of death. So, it seems that the only ethical approach is to inform people of the potential risk of sudden death by taking these drugs.

But we already know that genuine informed consent almost never happens. People are routinely told that the risk is minimal and the specifics are not stated. Ultimately, though, the only one who lives the the results are the person inside your own skin.

More Complete List of Drugs that Prolong the QT Interval

A 2004 article in the New England Journal of Medicine discusses prolongation of the QT interval. It listed the known drugs that can cause it[3]. They were:

Disopyramide
Dofetilide
Ibutilide
Procainamide
Quinidine
Sotalol
Bepridil
Amiodarone
Arsenic trioxide
Cisapride
Calcium-channel blockers: lidoflazine
Antiinfectives: clarithromycin, erythromycin, halofantrine, pentamidine, sparfloxacin
Antiemetics: domperidone, droperidol
Antipsychotics: chlorpromazine, halperidol, mesoridazine, thioridazine, pimozide
Methadone

Sources:

  1. QT interval and antidepressant use: a cross sectional study of electronic health records, BMJ; Victor M Castro, team lead, Caitlin C Clements, clinical research coordinator, Shawn N Murphy, associate professor of neurology, Vivian S Gainer, team lead, Maurizio Fava, Slater Family professor of psychiatry, Jeffrey B Weilburg, assistant professor of psychiatry, Jane L Erb, assistant professor of psychiatry, Susanne E Churchill, executive director, National Center for Biomedical Computing, Isaac S Kohane, director, National Center for Biomedical Computing, Dan V Iosifescu, associate professor of psychiatry, Jordan W Smoller, associate professor of psychiatry, Roy H Perlis, associate professor of psychiatry; doi: http://dx.doi.org/10.1136/bmj.f288 (Published 29 January 2013)
  2. citalopram (Rx) – Celexa
  3. Drug-Induced Prolongation of the QT Interval, New England Journal of Medicine; Alastair J.J. Wood, M.D., Editor


0 commentsback to post

Other articlesgo to homepage

Genetics Research Fraud: Your Genes do NOT Determine Your Health

Genetics Research Fraud: Your Genes do NOT Determine Your Health

Pin It

Your environment and lifestyle, particularly your diet, has a direct influence on your genetic expression. For example, research using identical twins have shown that diet trumps genes in terms of the level of health you achieve.

The science of epigenetics also challenges the conventional view of genetics, proving that the environment determines which traits a gene will express, and that your fate is in no way written in stone even if you have genetic predispositions.

It has become increasingly clear that there’s collusion going on between our government, industry, and scientists, to hide the fact that everything from human health and intellectual capacity to various addictions are indeed caused by the environment in which we find ourselves, NOT genetics and the failed science supporting it with billions of research dollars.

Knowing we are not salves to our genetic heritage offer tremendous amounts of hope for every single one of us, as it removes us from the position of victims of our heredity, and makes us masters of our own health and well-being.

Vaccine Scandals and Criminal Cases Increase in 2014

Vaccine Scandals and Criminal Cases Increase in 2014

Pin It

Criminal activities of pharmaceutical companies are frequently reported on in the mainstream media. The largest criminal settlements in U.S. history are cases against pharmaceutical companies, such as Johnson & Johnson’s $2.2 billion criminal settlement late last year for illegally marketing drugs to the elderly, children and the mentally disabled.

When it comes to criminal activities involved with marketing vaccines, however, there is a near total blackout in the mainstream media. So here at Health Impact News we will highlight a sampling of some of the biggest stories of fraud and criminal activities involved with marketing vaccines so far here in 2014.

Very few of these stories have been mentioned in the mainstream media, because the vaccine market is a multi-billion dollar market, and the vaccine industry does not like losing any market share. They are using their incestuous relationship to the U.S. government to take away personal rights and liberties in medical choices. They would like mandatory vaccine policies in place at the local, state, and national levels, because their products cannot survive in a free market. They need government collusion and coercion for this market to survive. And so far, with the help of the mainstream media generally not reporting on the corruption and criminal activity, they have a willing and compliant public.

The Flu Vaccine War: Healthcare Workers Fight Back

The Flu Vaccine War: Healthcare Workers Fight Back

Pin It

We have already established in previous articles that the flu vaccine is by far the most dangerous vaccine in the United States, injuring and killing many people every year based on settled court cases by the Department of Justice in the National Vaccine Injury Compensation Program.

And yet, hospitals across the country are mandating that healthcare workers receive the flu vaccine as a requirement to keep their employment. The main reason for this policy of forcing employees to receive the flu vaccine is not based on solid science that it protects patients (the science actually points towards no patient benefits), but based on funding requirements for medical reimbursements through Medicare and Medicaid, and through the Affordable Health Care Act, that require healthcare facilities to have a high compliance rate of employees receiving the flu vaccine.

Nurses, doctors, and other healthcare workers across the country are fighting back, however.

This week, he Massachusetts Nurses Association sued Brigham and Women’s Hospital in Boston to block a policy to require nurses to get flu shots as a condition of employment.

And this is not the first lawsuit in the country. Others have also taken action to protect their right to refuse medical treatments that are mandated as a condition to retain employment.

State Farm to Families of Vaccine-Damaged Children: We Don’t Need Your Business

State Farm to Families of Vaccine-Damaged Children: We Don’t Need Your Business

Pin It

Why would State Farm make such a controversial decision to pull one of their ads featuring someone who helped families with vaccine-injured children in private, knowing that they would lose customers over it? Could it be they were pressured to do so because they just jumped into the lucrative health insurance exchange business?

Learning When to Refuse Medical Treatment

Learning When to Refuse Medical Treatment

Pin It

Doctors today are over-prescribing diagnostic tests and drugs, and patients need to learn how to say “no” to their doctors. This message, surprisingly, is coming from the mainstream media. While this has been a clear message for many years now in the alternative media, that message is now going “mainstream.”

read more


Get the news right in your inbox!