July 30, 2014

Statins – Are YOU Taking These Dangerous Cholesterol Drugs?

pin it button Statins   Are YOU Taking These Dangerous Cholesterol Drugs?

By Dr. Mercola

Tens of millions of Americans are taking cholesterol-lowering drugs—mostly statins—and some “experts” claim that many millions more should be taking them. I couldn’t disagree more.

Statins are HMG-CoA reductase inhibitors, that is, they act by blocking the enzyme in your liver that is responsible for making cholesterol (HMG-CoA reductase).

The fact that statin drugs cause side effects is well established—there are now 900 studies proving their adverse effects, which run the gamut from muscle problems to increased cancer risk. For starters, reported side effects include:

Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis (a serious degenerative muscle tissue condition) Anemia
Acidosis Sexual dysfunction
Immune depression Cataracts
Pancreas or liver dysfunction, including a potential increase in liver enzymes Memory loss

Muscle problems are the best known of statin drugs’ adverse side effects, but cognitive problems and memory loss are also widely reported. A spectrum of other problems, ranging from blood glucose elevations to tendon problems, can also occur. There is evidence that taking statins may even increase your risk for Lou Gehrig’s disease, diabetes and even cancer. Statins currently available on the U.S. market include1 :

Advicor (lovastatin with niacin) – Abbott

Crestor (rosuvastatin) – AstraZeneca

Mevacor (lovastatin) – Merck

Simcor (niacin/imvastatin) – Abbott

Altoprev (lovastatin) – Shionogi Pharma

Lescol (fluvastatin) – Novartis

Pravachol (pravastatin) — Bristol-Myers Squibb

Zocor (simvastatin) – Merck

Caduet [atorvastatin with amlodipine (Norvasc)] – Pfizer

Lipitor (atorvastatin) – Pfizer

Vytorin (ezetimibe/simvastatin) – Merck/Schering-Plough

Statin Drugs: A Surprising Cause of Diabetes

Statins have been shown to increase your risk of diabetes through a few different mechanisms. The most important one is that they increase insulin resistance, which can be extremely harmful to your health. Increased insulin resistance contributes to chronic inflammation in your body, and inflammation is the hallmark of most diseases. In fact, increased insulin resistance can lead to heart disease, which, ironically, is the primary reason for taking a cholesterol-reducing drug in the first place! It can also promote belly fat, high blood pressure, heart attacks, chronic fatigue, thyroid disruption, and diseases like Parkinson’s, Alzheimer’s, and cancer.

Secondly, statins increase your diabetes risk by actually raising your blood sugar. When you eat a meal that contains starches and sugar, some of the excess sugar goes to your liver, which then stores it away as cholesterol and triglycerides. Statins work by preventing your liver from making cholesterol. As a result, your liver returns the sugar to your bloodstream, which raises your blood sugar levels.

Now, it’s important to realize that drug-induced diabetes and genuine type 2 diabetes are not necessarily identical.

If you’re on a statin drug and find that your blood glucose is elevated, it’s possible that what you have is just hyperglycemia—a side effect, and the result of your medication. Unfortunately, many doctors will at that point mistakenly diagnose you with “type 2 diabetes,” and possibly prescribe another drug, when all you may need to do is simply discontinue the statin in order for your blood glucose levels to revert back to normal. So if friends or loved ones you know are on a statin (and one in four Americans over 45 are) and they are told they have diabetes, please do them a favor and tell them about the information in this article.

Major Statin Drug Study Found to Be Flawed

A study known as the JUPITER trial initially suggested cholesterol-lowering statin drugs might prevent heart-related death in many more people than just those with high cholesterol. But two years after its publication in 2008, researchers came out saying the JUPITER results are flawed — and that they do not support the benefits initially reported. Not only is there no “striking decrease in coronary heart disease complications”, but a more recent report has also called into question drug companies’ involvement in such trials.

According to a report by ABC News2 :

“… major discrepancies exists between the significant reductions in nonfatal stroke and heart attacks reported in the JUPITER trial and what has been found in other research … ‘The JUPITER data set appears biased,’ [the researchers] wrote in conclusion.”

If You Take Statins, You MUST Take CoQ10

Statins deplete your body of CoQ10, which can have devastating results. If you take statin drugs without taking CoQ10, your health is at serious risk. Unfortunately, this describes the majority of people who take them in the United States. CoQ10 is a cofactor (co-enzyme) that is essential for the creation of ATP molecules, which you need for cellular energy production. Organs such as your heart have higher energy requirements, and therefore require more CoQ10 to function properly. Produced mainly in your liver, it also plays a role in maintaining blood glucose.

Physicians rarely inform people of this risk and only occasionally advise them to take a CoQ10 supplement. As your body gets more and more depleted of CoQ10, you may suffer from fatigue, muscle weakness and soreness, and eventually heart failure.

Coenzyme Q10 is also very important in the process of neutralizing free radicals. So when your CoQ10 is depleted, you enter a vicious cycle of increased free radicals, loss of cellular energy, and damaged mitochondrial DNA. If you decide to take a CoQ10 supplement and are over the age of 40, it is important to choose the reduced version, called ubiquinol. Ubiquinol is a FAR more effective form—I personally take it daily for its many far ranging benefits. As for dosage, Dr. Graveline, a family doctor and former astronaut, made the following recommendation in a previous interview on statins and CoQ10:

  • If you have symptoms of statin damage such as muscle pain, take anywhere from 200 to 500 mg
  • If you just want to use it preventively, 200 mg or less should be sufficient

Statins Impair Numerous Biological Functions

Statin drugs also interfere with other biological functions, including an early step in the mevalonate pathway, which is the central pathway for the steroid management in your body. Products of this pathway that are negatively affected by statins include:

  • All your sex hormones
  • Cortisone
  • The dolichols, which are involved in keeping the membranes inside your cells healthy
  • All sterols, including cholesterol and vitamin D (which is similar to cholesterol and is produced from cholesterol in your skin)

It’s still uncertain whether statins actually deplete your body of vitamin D, but they do reduce your body’s natural ability to create active vitamin D (1,25-dihydroxycholecalciferol). This is the natural outcome of the drug’s cholesterol-reducing ability, because you need cholesterol to make vitamin D! It’s the raw material your body uses for vitamin D conversion after you’ve exposed your skin to sunlight. It’s also well-documented that vitamin D improves insulin resistance, so needless to say, when you take a statin drug, you forfeit this ‘built-in’ health-promoting mechanism, which is yet another clue as to how statins can cause diabetes.

Ninety-Nine Out of 100 People do Not Need Statin Drugs

That these drugs have proliferated the market the way they have is a testimony to the power of marketing, corruption and corporate greed, because the odds are very high— greater than 100 to 1—that if you’re taking a statin, you don’t really need it. The ONLY subgroup that might benefit are those born with a genetic defect called familial hypercholesterolemia, as this makes them resistant to traditional measures of normalizing cholesterol.

And, even more importantly, cholesterol is NOT the cause of heart disease.

If your physician is urging you to check your total cholesterol, then you should know that this test will tell you virtually nothing about your risk of heart disease, unless it is 330 or higher. HDL percentage is a far more potent indicator for heart disease risk. Here are the two ratios you should pay attention to:

  1. HDL/Total Cholesterol Ratio: Should ideally be above 24 percent. If below 10 percent, you have a significantly elevated risk for heart disease.
  2. Triglyceride/HDL Ratio: Should be below 2.

I have seen a number of people with total cholesterol levels over 250 who were actually at low risk for heart disease due to their elevated HDL levels. Conversely, I have seen many people with cholesterol levels under 200 who had a very high risk of heart disease, based on their low HDL. Your body NEEDS cholesterol—it is important in the production of cell membranes, hormones, vitamin D and bile acids that help you to digest fat. Cholesterol also helps your brain form memories and is vital to your neurological function. There is also strong evidence that having too little cholesterol INCREASES your risk for cancer, memory loss, Parkinson’s disease, hormonal imbalances, stroke, depression, suicide, and violent behavior.

Statins Should NEVER Be Used By Pregnant Women

One in four Americans over the age of 45 is now taking these drugs, and few are properly warned about the related health risks. Part of the problem is that many doctors are not even aware of all the risks. A study published last spring highlighted this dilemma.

Most disturbingly, the researchers found that physicians were lacking in awareness of the teratogenic risks3 (ability to cause fetal malformations) of statins and other cardiovascular drugs they prescribed for their pregnant patients. The study followed an earlier report, which had concluded statins should be avoided in early pregnancy due to their teratogenic capability4 . An even earlier 2003 study5 had already established that cholesterol plays an essential role in embryonic development, and that statins could play a part in embryonic mutations or even death…

Indeed, it’s difficult to look at these facts and not reach the conclusion that the pharmaceutical industry is quite willing to sacrifice human lives for profit. Statins are in fact classified as a “pregnancy Category X medication” meaning, it causes serious birth defects, and should NEVER be used by a woman who is pregnant or planning a pregnancy.

Parents Beware: Outrageous Push to Put Kids on Statin Drugs!

In a bold attempt to increase profits before the patent runs out, Pfizer has introduced a chewable kid-friendly version of Lipitor. Its US patent for Lipitor expired in November 2011, and seeking to boost sales of the drug, children have become the new target market, and the conventional medical establishment is more than happy to oblige.

Researchers and many doctors are now calling for universal school screening of children to check for high cholesterol, to find those “in need of treatment.” In addition, older siblings, parents and other family members might be prompted to get screened as well, the researchers say, which would uncover additional, previously undiagnosed adults in need of the drug.

This is clearly NOT the way to improve public health. On the contrary, it could produce a new, massive wave of extremely dire health consequences in just a few years time.

So rather than improving school lunches, which would cost about a dollar a day per child, they’d rather “invest” ten times that for tests and drugs that in no way, shape, or form address the root cause, which is an improper, unhealthy diet! All they’re doing is allowing all the industries to maintain or increase their profits: Big Pharma; Big Sugar; Big Corn and the processed food industry.

Who pays?

You, and your children! And in far more ways than one!

Optimizing Your Cholesterol Levels, Naturally

There’s really no reason to take statins and suffer the damaging health effects from these dangerous drugs. The fact is that 75 percent of your cholesterol is produced by your liver, which is influenced by your insulin levels. Therefore, if you optimize your insulin level, you will automatically optimize your cholesterol. It follows, then, that my primary recommendations for safely regulating your cholesterol have to do with modifying your diet and lifestyle:

  • Optimize your vitamin D levels. Research by Dr. Stephanie Seneff has shed additional light on the extreme importance of appropriate sun exposure for normalizing your cholesterol levels and preventing heart disease. For more information, please see this previous interview.
  • Reduce, with the plan of eliminating, grains and sugars in your diet. Ideally, you’ll also want to consume a good portion of your food raw.
  • Make sure you are getting plenty of high quality, animal-based omega 3 fats, such as krill oil.
  • Other heart-healthy foods include olive oil, coconut and coconut oil, organic raw dairy products and eggs, avocados, raw nuts and seeds, and organic grass-fed meats as appropriate for your nutritional type.
  • Exercise daily. Make sure you incorporate peak fitness exercises, which also optimizes your human growth hormone (HGH) production.
  • Address your emotional challenges. My favorite technique for stress management is the Emotional Freedom Technique (EFT).
  • Avoid smoking or drinking alcohol excessively.
  • Be sure to get plenty of good, restorative sleep.

Unlike statin drugs, which lower your cholesterol at the expense of your health, these lifestyle strategies represent a holistic approach that will benefit your overall health—which includes a healthy cardiovascular system.

The Baycol Statin Recall and Safety Issue:

In August 2001, Bayer AG, the maker of Baycol (cerivastatin), a popular cholesterol-lowering drug used by about 700,000 Americans, pulled the medicine off the market after 31 people died from severe muscle breakdown, a well-recognized side effect of cholesterol-lowering drugs. Related articles follow:

Statins: Is the Danger in the Dose? Here is the hard data on Baycol-associated adverse reactions. If you or someone you know is taking one of the statin cholesterol-lowering drugs, this is a “must-read” article by Jay Cohen, MD to help you understand the potential dangers that this exposes you to.

Baycol Pulled From Market as Numerous Deaths Linked to It

Baycol, a cholestrol-lowering drug (statin), has been voluntarily pulled off the market because of numerous deaths associated with its use.

The Baycol Recall: How Safe is Your Statin?

With the recall of Baycol, patients are now searching out a new drug to take its place, but are other statins really safe? Here are some precautions necessary for anyone taking Baycol or any statin.

Baycol: Another Fluoride Drug Bites the Dust

Baycol is just one of many fluoride drugs to be pulled from the market due to health hazards posed. Read about this and some of the others in this informative article written by Andreas Schuld and Wendy Small.

BMJ: Bayer faces potential fine over cholesterol lowering drug

Bayer might have to pay a fine to the German government of about $23,400 for withholding from the German authorities information on the drug’s potentially fatal interaction with another drug.

Lipitor Tied to Liver, Kidney Injury, as Well as Muscle Damage

It seems that Baycol is not alone among cholesterol lowering drugs in posing serious dangers to the public. A number of legal actions are also being pursued against Pfizer Inc., the manufacturer of the Lipitor.

Excerpts from Public Citizen’s Health Research Group’s Petition to Require a Box Warning on All HMG-CoA Reductase Inhibitors (“Statins”):

” … Public Citizen, representing 135,000 consumers nationwide, hereby petitions the FDA pursuant to the Federal Food, Drug and Cosmetic Act 21, U.S.C. Section 355(e)(3), and C.F.R. 10.30, to add a black box warning and additional consistent bolded warnings about this serious problem to the label of all statins marketed in the United States.”

“Doctors and the public must be warned to immediately discontinue use of statin drugs at the onset of muscle pain, muscle tenderness, muscle weakness or tiredness.”

“Prompt cessation of the use of statins at the first sign of muscle pain, muscle tenderness, muscle weakness or tiredness and prompt evaluation by a physician including a blood test for creatine phosphokinase (a measure of muscle destruction) may avoid the progression to more extensive muscle damage, rhabdomyolysis and death.”

“Rhabdomyolysis has been reported with all statins currently marketed in the United States.”

About the Experts

Joseph Mercola, DO

Founder and Owner of Mercola.com.

Uffe Ravnskov, MD

Born 1934 in Copenhagen, Denmark Graduated 1961 from the University of Copenhagen with an M.D. 1961-1967: Various appointments at surgical, roentgenological, neurological, pediatric and medical departments in Denmark and Sweden. 1968-1979: Various appointments at the Department of Nephrology, and the Department of Clinical Chemistry, University Hospital, Lund, Sweden. 1975-79: As an assistant professor at the Department of Nephrology. 1973: PhD at the University of Lund. 1979-2000: A private practitioner. Since 1979 an independent researcher. A specialist in internal medicine and nephrology. Honored by the Skrabanek Award 1998.

For more information about him, see Dr. Ravnskov’s Web site.

Jay Cohen, M.D

Jay Cohen, M.D., is an associate professor of Family and Preventative Medicine and of Psychiatry at the University of California in San Diego. He is the author of two books and has numerous papers published in peer-reviewed journals. His book, Over Dose: The Case Against the Drug Companies, is an outstanding read.

 

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