Latest Alzheimer’s Blockbuster Drug Fails to Complete Phase 3 Trials

As has been reported numerous times here at Health Impact News for the past 6 years or so, the pharmaceutical industry has been desperate to find an Alzheimer's drug to market to an aging baby boomer population with ever increasing numbers of Alzheimer's Disease cases. And yet, billions of dollars have been invested in potential drugs only to see these drugs never make it out of the trial phase and come to market, because they do not significantly help Alzheimer's patients. Biogen and their partner Eisai are the latest pharmaceutical companies to throw in the towel regarding their Alzheimer's drug aducanumab, which has failed to make it out of phase 3 trials. Many drug researchers have now abandoned the theory of amyloid plaque accumulation in the brain as the causative factor of Alzheimer’s. Could aducanumab's failure be the last nail in the coffin for this theory, as natural approaches to Alzheimer's such as coconut oil and the ketogenic diet see more positive results?

New Research: Black Seed Oil Effective in Treating Alzheimer’s and Ischemia Organ Damage

A centuries-old healing agent, Nigella sativa (N. sativa) aka black cumin seeds, often pressed to create black seed oil, has been scrutinized by science to confirm what traditional healers have known for ages: N. sativa is preventative and curative for many ailments without the side effects of modern pharmaceutical drugs. Two recently published journal articles looked at how black seeds can heal organ ischemia damage and prevent or help Alzheimer's disease.

Research Shows High-Fat Low-Carb Diet with Coconut Oil Can Prevent or Cure Alzheimer’s

A very recent review on nutritional approaches toward preventing and reversing Alzheimer’s disease (AD) was conducted in Christchurch, New Zealand’s Canterbury University. The results were submitted to the journal Nutrition. It’s title: "The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease." After analyzing 33 studies researching AD and other neurological disorders handled with a ketogenic diet and supplementing coconut oil, the University of Canterbury review analysis concluded: "In this review, we hypothesize that the ketogenic diet could be an effective treatment and prevention for Alzheimer's disease, but both ketone production and carbohydrate restriction may be needed to achieve this."

As Alzheimer’s Drugs Continue to Fail, Researchers Search for Reasons Why Coconut Oil Cures Alzheimer’s

A group of New York City’s Mt. Sinai Medical School researchers set out to analyze why and how coconut oil affects Alzheimer’s Disease (AD) patients favorably. They acknowledged some efficacy from coconut oil, and they wanted to know more. Since most drug trials to develop an Alzheimer's drug have failed miserably, the motivation to study coconut oil in order to understand how it positively affects AD was probably motivated by a desire to patent a new drug that could work similar to coconut oil, a natural food that cannot be patented. Their research was based on earlier animal studies of virgin coconut oil’s effect on mouse models of coconut oil as well as other in vitro (lab culture) studies. The researchers also acknowledged the existence of many anecdotal testimonies of AD (Alzheimer’s disease) patients. The Mt. Sinai report was published in the journal Science Direct, Brain Research with the title: Coconut oil decreases expression of amyloid precursor protein (APP) and secretion of amyloid peptides through inhibition of ADP-ribosylation factor 1 (ARF1).

Photobiomodulation Technology is Healing Neurological Diseases

It is well established that, so far, nothing the pharmaceutical industry has concocted has done anything positive for treating Alzheimer's, Parkinson's, ALS (amyotrophic lateral disease), MLS (multiple sclerosis), strokes, or any other neurological issue. Pharmaceuticals tend to be ineffective with too many side effects to even promote. Thus, these neurological conditions tend to be categorized as “incurable,” leaving most hopeless. The result is years of mentally-impaired living that’s a burden to everyone involved until death, which some consider “premature.” Nevertheless, some successful, natural, dietary and vitamin-mineral supplemental methods have been developed that mainstream media ignores and mainstream medicine marginalizes. They’re not FDA approved, because the FDA only approves pharmaceutical drugs. But most of these natural cures can be applied on a do-it-yourself basis, and the FDA can’t stop that. Currently, near-infrared light has been discovered to be safe and effective against all sorts of neurological pathologies.

Study: Virgin Coconut Oil Reduces Effects of Aluminium Chloride-induced Alzheimer’s

Another study has been published here in 2018 looking at the positive effects of virgin coconut oil for Alzheimer's disease. This is the third peer-reviewed study we have covered so far in 2018 looking at the effects of coconut oil on Alzheimer's Disease (AD). This latest study is titled "Possible prophylactic anti-excitotoxic and anti-oxidant effects of virgin coconut oil on aluminium chloride-induced Alzheimer's in rat models." It was published July 13, 2018, in the "Journal of Integrative Neuroscience." The study was conducted by researchers from the Faculty of Medicine at King Abdulaziz University in Saudi Arabia. This year's previous studies on AD and coconut oil were also conducted outside of the U.S. (Japan and Iran.) This study is significant, because it addresses the issue of aluminum toxicity, which has been increasingly linked to AD. (See: Study: High Amounts of Aluminum in Brains of Alzheimer’s Patients.) From the study abstract: "Alzheimer’s disease (AD) is a progressive neurodegenerative disease that affects an estimated 5.4 million people worldwide. However, there remains no curative treatment for the condition. Aβ and hyperphosphorylated tau accumulation are the main hallmarks of the disease; they interfere with glutamate uptake and mediate glutamate excitotoxicity, oxidative stress, inflammation and neurodegeneration. As virgin coconut oil (VCO) is well-known as an antioxidant and anti-inflammatory natural compound, the purpose of the present study was to assess the possible prophylactic effect of VCO on aluminium chloride (AlCl3)- induced AD in rat."

Study: Virgin Coconut Oil Reduces Aβ Plaques, Inflammation, and Oxidative Stress Associated with Alzheimer’s Disease

A study published in August 2018 in the journal Food and Chemical Toxicology confirms what many people have already discovered: coconut oil can improve or even reverse the effects of Alzheimer's Disease. This is believed to be the first peer-reviewed study to examine coconut oil's effect on Alzheimer's Disease. The title of the study is "Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat." Researchers from Kermanshah University of Medical Sciences and Hamadan University of Medical Sciences in Iran used rats in a laboratory to study "the effects of virgin coconut oil (VCO) on inflammasome and oxidative stress in an Alzheimer's model." Their study found that the rats fed VCO "improved hippocampus histological changes, reduced Aβ plaques and phosphorylated Tau." (Phosphorylated Tau is a biological marker for Alzheimer's Disease.) They concluded that virgin coconut oil "showed potential neuroprotective effects." From the study conclusion: "Virgin Coconut Oil improves the health of the hippocampus and improves memory and learning in Alzheimer and HFD model rats by inhibiting inflammasome and reducing oxidative stress."

The High-fat Ketogenic Diet for Cognitive Health: Proven Remedies for the Alzheimer’s Epidemic

The failure of Big Pharma to develop an Alzheimer's drug has been well-documented in the corporate-sponsored "mainstream" media. As Alzheimer's diagnoses continue to increase, drug companies are scrambling to develop the next big drug to market to seniors. In modern times, the most successful drugs in sales, so far, have been cholesterol-lowering statin drugs, as one out of every five people over the age of 50 are now taking drugs to lower one's cholesterol, raking in billions of dollars for pharmaceutical companies. The sick irony to this is that lowering one's cholesterol artificially is directly linked to declining cognitive health and diseases such as Alzheimer's, since 25% of one's total cholesterol is located in the brain. The failed scientific hypothesis behind these drugs is that cholesterol is a cause of heart disease, and that diets high in saturated fats contribute to high cholesterol. However, the actual science shows almost the opposite, and when one looks at death rates, for example, lower cholesterol rates do not equate to longer life - in fact the converse is true: higher cholesterol levels lead to longer life spans. The pharmaceutical industry and the U.S. government cannot afford to reverse their warnings against saturated fats and cholesterol, however, as it would be the same as confessing that the entire statin drug industry has been a scam, and that statin drugs actually cause more harm than good. This is the main reason why the USDA must continue supporting a low-fat diet and condemning saturated fats, even though the science does not support their positions. It is no surprise, therefore, to learn that peer-reviewed scientific studies continue to show that the high-fat ketogenic diet supports cognitive health and can help prevent or reduce cognitive diseases such as Alzheimer's. Here are four new studies just published on the high-fat ketogenic diet related to cognitive health, and preventing Alzheimer's Disease.

Big Pharma’s Continued Failure to Develop an Effective Alzheimer’s Drug: Are Alzheimer’s Vaccines Next?

Coconut oil and the high-fact ketogenic diet have proven effective and safe at treating dementia, Parkinson’s disease, and Alzheimer’s. Meanwhile, the pharmaceutical industry’s continued effort at finding drugs to ameliorate Alzheimer’s and Parkinson’s have been a complete failure. There’s too much potential profit in the baby-boomer-turning-seniors market for them to stop; Big Pharma’s boom with cholesterol-lowering statin drugs proved that. There are still way too many who have put their faith in modern mainstream medicine, especially among baby boomers. The next blockbuster drug revenue with Alzheimer’s and Parkinson’s may be with a new Alzheimer vaccine, since vaccines introduced into the market do not need to be effective, and drug companies cannot be sued for any damages resulting from vaccines.

Study: High Amounts of Aluminum in Brains of Alzheimer’s Patients

There have been unconfirmed suspicions that aluminum toxicity is at least a factor for dementia and Alzheimer’s disease. There seems to be no doubt that aluminum is a neurotoxin, but whether there is an aluminum link to Alzheimer’s and other forms of dementia, has not been fully explored just recently. A new study, “Aluminium [British spelling] in brain tissue in familial Alzheimer’s disease” does just that. A pathological brain study of deceased individuals whose bodies were donated by family members. It was conducted in King’s College of London and Keele University of Staffordshire, UK, and published December 2016 in the Journal of Trace Elements in Medicine and Biology. The study’s conclusion: "Aluminium is neurotoxic and the concentrations of aluminium found in these familial AD brains are unlikely to be benign and indeed are highly likely to have contributed to both the onset and the aggressive nature of any ongoing AD in these individuals. These data lend support to the recent conclusion that brain aluminium will contribute towards all forms of AD under certain conditions."