October 20, 2014

Why New Antidepressant Brintellix May Be a Killer

pin it button Why New Antidepressant Brintellix May Be a Killer

Brintellix and Death Caduceus Why New Antidepressant Brintellix May Be a Killer

by Heidi Stevenson
Gaia-Health.com

Brintellix is being marketed with implications that it’s the best antidepressent yet and that it’s exceptionally safe. What is this based on? Close examination shows the usual smoke and mirrors, and an even closer look points out disturbing indications of potentially devastating and deadly effects—with no indication that it’s better than existing SSRIs, which are known killers.

One of the most devastating classes of drugs ever developed is antidepressant SSRIs, selective serotonin receptor inhibitors. Not only can they destroy your own life, but they can also turn you into a murderer. Now, the FDA has approved Brintellix, which may prove to be the worst of them all.

In a press release by pharmaceutical company Lundbeck, the developer of Brintellix[1], it’s admitted that the cause of depression is unknown. Nonetheless, they cavalierly play with brain chemistry about which they know very little. Making this particular drug potentially even worse than any other SSRI is that it doesn’t limit itself to one or two pathways in the brain. It manipulates a total of 6 receptors!

Although Takeda Pharmaceuticals and Lundbeck, the US distributors, are expecting Brintellix to become a blockbuster drug, the hyped studies that appear to demonstrate both efficacy and safety are far from the full story. In fact, some studies have shown no benefit over placebo whatsoever.[2] It’s apparent from their approval announcement that the FDA did not take studies with negative results into account. They referred to only 6 studies, which the agency states, “demonstrated that Brintellix is effective in treating depression”.[3]

SSRIs

SSRIs do not work as claimed. They interfere with normal brain functioning. They don’t stop depression. Instead, they stop the ability to feel emotions. They result in emotional flatness. Some people may find that beneficial, something of a time-out. But it never resolves the problems that lead to depression, and even interferes with resolution. How can anyone resolve a problem when a drug interferes with their ability to even know that it’s there?

All SSRIs do the same thing. They prevent serotonin, also called 5-HT, from being reabsorbed, as their name, selective “serotonin reuptake inhibitors”, indicates. That hasn’t turned out well. These drugs are now known to cause previously nonsuicidal people to take their own lives without warning. They have also made many people violent and are associated with almost all school shootings.

There is little reason to believe that Brintellix will be more effective than other SSRI antidepressants. In fact, the more SSRIs manage to shut down serotonin production, the more harm they do. The brain works to counter the effect. As Dr. Peter Brennan notes, it can result in permanent brain damage.[4]

In fact, the Los Angeles Time reported that Dr. Michael Thase, a Brintellix development consultant, stated:

It is different enough from the welter of SSRIs currently available that it’s not simply a ‘me too’ drug.[5]

That’s likely true, but does that  make it better?

Brintellix May Be Even Worse

Inexplicable violence, turned both inward and outward, is the result of SSRIs causing a single change to brain function. Brintellix will cause several changes! These changes involve the handling of glutamate, which is a critical amino acid that’s required for brain function and cellular metabolism. Glutamate is necessary—at proper levels, in the right places, and at the right times—for learning, remembering, thinking, and emotions. It’s also involved in energy production throughout the body.

Glutamate excites neural function. Too much glutamate can burn nerves out and too little keeps them from functioning properly. Not only does Brintellix manipulate 5-HT (serotonin), like all other SSRIs, it also manipulates glutamate in several neural receptors:

  • 5-HT1A: Agonist
  • 5-HT1B: Partial Agonist
  • 5-HT3: Antagonist
  • 5-HT1D: Antagonist
  • 5-HT7: Antagonist

Note: An agonist triggers a response from a cell. An antagonist does the opposite. It blocks a cell’s response.

Does anyone really know what the effects of this manipulation of neural transmission will be?

No. Here is what the manufacturer’s press release announcing Brintellix’s approval says about it:

The contribution of each of these activities to Brintellix’s antidepressant effect has not been established. It is considered to be the first and only compound with this combination of pharmacodynamic activity. The clinical relevance of this is unknown.

Let’s look at that again:

No one knows what relationship exists between any of these neural receptors and Brintellix’s effect.

No one knows what these manipulations of the brain will do to the body, intelligence, emotional state, sexuality, criminality, empathy, or anything else.

Nearly all the effects of Brintellix are unknown.

How Much Harm?

Like so many drugs, Brintellix is being rolled out as safe. Like others, that safety is based on a very slim thread: short term studies, which evade the risks. The existing studies produced by Lundbeck are short term, and many adverse effects take time to be seen. They’re also based on a small number of subjects. Most severe adverse effects don’t show up in such studies.

At this point, the list of adverse effects is both brief and appears to be fairly minor. Medscape[6]reports the following adverse effects, followed by the percentage who suffered it:

  • Nausea: 21-32%
  • Diarrhea: 7-10%
  • Dizziness: 6-9%
  • Dry mouth: 6-8%
  • Constipation: 3-6%
  • Vomiting: 3-6%
  • Flatulence: 1-3%
  • Pruritus: 1-3%
  • Abnormal Dreams: Less than 1-3%

These adverse effects are not as innocent as they first appear. Notice that as many as a third of the subjects suffered from nausea, and other gastrointestinal effects were not unusual. This is a red flag that there may be a dangerous adverse effect on the digestive tract that doesn’t show up quickly—not something to take lightly.

Dizziness and abnormal dreams are indicative of very serious harmful neurological effects. Pruritus is a neurologically-induced extreme urge to scratch an itch. This symptom is also indicative of neurological damage. Even at this early stage, the adverse effects point to the potential of severe and dangerous, potentially deadly, reactions.

The history of all other SSRIs, which interfere with only one specific function, has been dismal. Is there any reason to expect Brintellix to be different? The studies certainly aren’t more extensive than they’ve been with other SSRIs, so the reality is that, as usual, the people whose doctors prescribe it will be the guinea pigs.

If your doctor tries to prescribe Brintellix, perhaps the correct response should be, “Oink!”

Even Big Pharma’s faithful lapdog called the FDA has acknowledged some risk. They’re requiring a boxed warning that people younger than 24 years are at risk of developing suicidal thoughts. This, of course, is meaningless. All SSRIs carry that warning, and it certainly doesn’t seem to have reduced prescription levels!

SSRI = Killer

As the FDA admits, all SSRI drugs are known to be killers, and worse than most drugs, they can result in the deaths of people who don’t even take them! They are implicated in virtually all the school shootings. That’s a lot of carnage.

Brintellix is an SSRI. Is there any reason to believe that it will produce less harm than other SSRIs? In fact, there is every reason to suspect the opposite.

By its developer’s own admission, no one knows what effects are produced by 5 of the 6 functions Brintellix was designed to cause. But we do know that the 6th function, serotonin/5-HT reuptake inhibition, is a killer. All of the other 5 functions interfere with normal brain activity—and the manufacturer admits that no one knows what those effects will be!

 What more do you need to know?

Read the full article here: http://gaia-health.com/gaia-blog/2013-10-04/why-new-antidepressant-brintellix-may-be-a-killer/

Sources:

  1. Takeda and Lundbeck announce FDA approval of Brintellix™ (vortioxetine) for treatment of adults with major depressive disorder. Lundbeck’s Brintellix press release.
  2. Antidepressant – vortioxetine. Manufacturer’s Chemist’s review of Brintellix.
  3. FDA approves new drug to treat major depressive disorder. FDA’s Brintellix approval announcement.
  4. Psychiatric drug-induced Chronic Brain Impairment (CBI): Implications for longterm treatment with psychiatric medicationInternational Journal of Risk and Safety in Medicine; DOI 10.3233/JRS-2011-0542.
  5. FDA approves a new antidepressant: BrintellixLos Angeles Times.
  6. Vortioxetine Adverse Effects; Medscape Reference.
  7. Vortioxetine (Lu AA21004) hydrobromide.
  8. Glutamate.
  9. Glutamate benefit and side effects, risk and danger.
  10. Vortioxetine: A New Antidepressant Choice in the United States

The Emperor’s New Drugs
Exploding the Antidepressant Myth
by Irving Kirsch Ph.D.

The Emperors New Drugs Book cover 202x300 Why New Antidepressant Brintellix May Be a Killer

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Boston Nurses Speak Out Against Mandatory Flu Shots

Boston Nurses Speak Out Against Mandatory Flu Shots

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Last month (September 2014) the Massachusetts Nurses Association sued Brigham and Women’s Hospital over a new policy that required nurses to receive the annual flu vaccine as a condition for employment.

The nurses were, of course, criticized by the medical establishment. They were accused of putting their own interests above the needs of patients. Lynn Nicholas, president of the Massachusetts Hospital Association, stated that the nurses were: “putting a pet peeve of theirs above the safety and well-being of the patients they serve, their families, visitors to the hospital, and their colleagues.”

Pet peeve? Really?

When nurses all across the United States and Canada are willing to sacrifice their jobs and careers to avoid the annual flu shot, it is time to sit up and take notice. This is obviously something much more than a “pet peeve.”

Trish Powers, representing Brigham nurses in Boston fired back a comment that The Boston Globe published. It is titled “Brigham nurses know flu vaccine can do harm.”

Gardasil: The Day Our Daughter’s Life Changed

Gardasil: The Day Our Daughter’s Life Changed

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The Gardasil vaccine has changed Skylee’s life in so many ways and we do not know how many more symptoms will show up and change her life even more than it has already done. Our whole family has been affected by this vaccine and all of our lives have been turned upside down that terrible day in 2013.

If only the doctors would recognize Skylee has gone from being a healthy young girl to an invalid when the only major change in her life occurred on the day she had that single shot of Gardasil.

Will There Be An Ebola Outbreak in America?

Will There Be An Ebola Outbreak in America?

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So here is what inquiring minds want to know:

Why did U.S. health officials in Atlanta and on the ground in Africa ignore the exploding Ebola epidemic last spring?

Why did U.S. government officials fly American aid workers infected with Ebola to the U.S. rather than treating them with experimental drugs at hospitals in Africa?

Why did the U.S. government press the United Nations to adopt a resolution calling for no restrictions on international travel from Liberia and other Ebola-stricken countries?

Why did the Centers for Disease Control, supposedly the world’s leading infection control agency, fail to immediately assist Texas health officials when the first case of Ebola was diagnosed on US soil to guarantee that, at a minimum, the kind of infection control measures used in most nursing homes in America would be carried out?

Why has the Director of the CDC repeatedly stated that the only way a person can transmit Ebola is if they have a fever and said that people cannot get Ebola unless they have direct contact with the body fluids of an infected person – but that under no circumstances is Ebola airborne – when he knows, or should know, those statements could be false?

And why are experimental Ebola vaccines being fast tracked into human trials and promoted as the final solution rather than ramping up testing and production of the experimental ZMapp drug that has already saved the lives of several Ebola infected Americans?

A logical conclusion is that some people in industry, government and the World Health Organization did not want the Ebola outbreak to be confined to several nations in Africa because that would fail to create a lucrative global market for mandated use of fast tracked Ebola vaccines by every one of the seven billion human beings living on this planet.

Similarities Between 1976 Swine Flu Hoax and Ebola?

Similarities Between 1976 Swine Flu Hoax and Ebola?

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Read this before you consider purchasing a hazmat suit to protect yourself from Ebola!

Are we facing an Ebola pandemic that will kill millions, or is this just a marketing plan of the pharmaceutical industry to sell more drugs and vaccines? Is the current strain of the Ebola virus a secret creation of pharmaceutical company scientists, biological warfare researchers, or the fruit of Monsanto’s product development team?

Was Ebola created, or did it just accidentally spill over into humans from an animal host such as African fruit bats?

Is the US government intentionally not taking strong action to prevent Ebola from spreading or is there really minimal risk to Americans? Are there groups that want to decrease the world population through spreading contagious diseases such as Ebola, or is this just another imaginary plan that is being reported by certain conspiracy theory groups?

Is the Ebola virus a local epidemic, a global pandemic, or a hoax? Is life in America as we have known it about to collapse into chaos and martial law, or will we be safe and secure once we take the Ebola vaccine?

Will more people die from the Ebola vaccine than would have died from the disease itself?

All these questions have been circulating through the media over the last few months. The situation with Ebola is certainly a complex muddle of contradictory facts, opposing interpretations, and political intrigue. It reminds me very much of the 1976 Swine flu hoax — commonly called the swine flu fiasco or the swine flu debacle. More:

6 Reasons I Won’t Give My Kids The Nasal Flu Vaccine

6 Reasons I Won’t Give My Kids The Nasal Flu Vaccine

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It’s flu season again, and the push to get everyone in America vaccinated for the flu vaccine is in full swing. Please be aware that those who want you to receive the flu vaccine admittedly do not want you to know about the risks associated with the vaccine. They actively try to suppress information that would educate people on the dangers and risks of the flu vaccine and decrease their sales.

To hear the other side of the vaccine debate from a medical doctor the media would like to censor, please watch the video by Dr. Suzanne Humphries here: Dr. Suzanne Humphries on Vaccine Safety: “They Don’t Want You to Hear the Other Side”

Secondly, please look at the settled cases for vaccine injuries and deaths due to the flu vaccine the U.S. government pays out to victims: Flu Vaccine is the most Dangerous Vaccine in the U. S. based on Settled Cases for Injuries. This information is not published in the mainstream media.

This year, there is a heavy push on to give kids the nasal flu vaccine. Celeste McGovern, writing for GreenMedInfo.com, gives 6 reasons why she will not be giving this vaccine to her children.

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