September 1, 2014

Why New Antidepressant Brintellix May Be a Killer

pin it button Why New Antidepressant Brintellix May Be a Killer

Brintellix and Death Caduceus Why New Antidepressant Brintellix May Be a Killer

by Heidi Stevenson
Gaia-Health.com

Brintellix is being marketed with implications that it’s the best antidepressent yet and that it’s exceptionally safe. What is this based on? Close examination shows the usual smoke and mirrors, and an even closer look points out disturbing indications of potentially devastating and deadly effects—with no indication that it’s better than existing SSRIs, which are known killers.

One of the most devastating classes of drugs ever developed is antidepressant SSRIs, selective serotonin receptor inhibitors. Not only can they destroy your own life, but they can also turn you into a murderer. Now, the FDA has approved Brintellix, which may prove to be the worst of them all.

In a press release by pharmaceutical company Lundbeck, the developer of Brintellix[1], it’s admitted that the cause of depression is unknown. Nonetheless, they cavalierly play with brain chemistry about which they know very little. Making this particular drug potentially even worse than any other SSRI is that it doesn’t limit itself to one or two pathways in the brain. It manipulates a total of 6 receptors!

Although Takeda Pharmaceuticals and Lundbeck, the US distributors, are expecting Brintellix to become a blockbuster drug, the hyped studies that appear to demonstrate both efficacy and safety are far from the full story. In fact, some studies have shown no benefit over placebo whatsoever.[2] It’s apparent from their approval announcement that the FDA did not take studies with negative results into account. They referred to only 6 studies, which the agency states, “demonstrated that Brintellix is effective in treating depression”.[3]

SSRIs

SSRIs do not work as claimed. They interfere with normal brain functioning. They don’t stop depression. Instead, they stop the ability to feel emotions. They result in emotional flatness. Some people may find that beneficial, something of a time-out. But it never resolves the problems that lead to depression, and even interferes with resolution. How can anyone resolve a problem when a drug interferes with their ability to even know that it’s there?

All SSRIs do the same thing. They prevent serotonin, also called 5-HT, from being reabsorbed, as their name, selective “serotonin reuptake inhibitors”, indicates. That hasn’t turned out well. These drugs are now known to cause previously nonsuicidal people to take their own lives without warning. They have also made many people violent and are associated with almost all school shootings.

There is little reason to believe that Brintellix will be more effective than other SSRI antidepressants. In fact, the more SSRIs manage to shut down serotonin production, the more harm they do. The brain works to counter the effect. As Dr. Peter Brennan notes, it can result in permanent brain damage.[4]

In fact, the Los Angeles Time reported that Dr. Michael Thase, a Brintellix development consultant, stated:

It is different enough from the welter of SSRIs currently available that it’s not simply a ‘me too’ drug.[5]

That’s likely true, but does that  make it better?

Brintellix May Be Even Worse

Inexplicable violence, turned both inward and outward, is the result of SSRIs causing a single change to brain function. Brintellix will cause several changes! These changes involve the handling of glutamate, which is a critical amino acid that’s required for brain function and cellular metabolism. Glutamate is necessary—at proper levels, in the right places, and at the right times—for learning, remembering, thinking, and emotions. It’s also involved in energy production throughout the body.

Glutamate excites neural function. Too much glutamate can burn nerves out and too little keeps them from functioning properly. Not only does Brintellix manipulate 5-HT (serotonin), like all other SSRIs, it also manipulates glutamate in several neural receptors:

  • 5-HT1A: Agonist
  • 5-HT1B: Partial Agonist
  • 5-HT3: Antagonist
  • 5-HT1D: Antagonist
  • 5-HT7: Antagonist

Note: An agonist triggers a response from a cell. An antagonist does the opposite. It blocks a cell’s response.

Does anyone really know what the effects of this manipulation of neural transmission will be?

No. Here is what the manufacturer’s press release announcing Brintellix’s approval says about it:

The contribution of each of these activities to Brintellix’s antidepressant effect has not been established. It is considered to be the first and only compound with this combination of pharmacodynamic activity. The clinical relevance of this is unknown.

Let’s look at that again:

No one knows what relationship exists between any of these neural receptors and Brintellix’s effect.

No one knows what these manipulations of the brain will do to the body, intelligence, emotional state, sexuality, criminality, empathy, or anything else.

Nearly all the effects of Brintellix are unknown.

How Much Harm?

Like so many drugs, Brintellix is being rolled out as safe. Like others, that safety is based on a very slim thread: short term studies, which evade the risks. The existing studies produced by Lundbeck are short term, and many adverse effects take time to be seen. They’re also based on a small number of subjects. Most severe adverse effects don’t show up in such studies.

At this point, the list of adverse effects is both brief and appears to be fairly minor. Medscape[6]reports the following adverse effects, followed by the percentage who suffered it:

  • Nausea: 21-32%
  • Diarrhea: 7-10%
  • Dizziness: 6-9%
  • Dry mouth: 6-8%
  • Constipation: 3-6%
  • Vomiting: 3-6%
  • Flatulence: 1-3%
  • Pruritus: 1-3%
  • Abnormal Dreams: Less than 1-3%

These adverse effects are not as innocent as they first appear. Notice that as many as a third of the subjects suffered from nausea, and other gastrointestinal effects were not unusual. This is a red flag that there may be a dangerous adverse effect on the digestive tract that doesn’t show up quickly—not something to take lightly.

Dizziness and abnormal dreams are indicative of very serious harmful neurological effects. Pruritus is a neurologically-induced extreme urge to scratch an itch. This symptom is also indicative of neurological damage. Even at this early stage, the adverse effects point to the potential of severe and dangerous, potentially deadly, reactions.

The history of all other SSRIs, which interfere with only one specific function, has been dismal. Is there any reason to expect Brintellix to be different? The studies certainly aren’t more extensive than they’ve been with other SSRIs, so the reality is that, as usual, the people whose doctors prescribe it will be the guinea pigs.

If your doctor tries to prescribe Brintellix, perhaps the correct response should be, “Oink!”

Even Big Pharma’s faithful lapdog called the FDA has acknowledged some risk. They’re requiring a boxed warning that people younger than 24 years are at risk of developing suicidal thoughts. This, of course, is meaningless. All SSRIs carry that warning, and it certainly doesn’t seem to have reduced prescription levels!

SSRI = Killer

As the FDA admits, all SSRI drugs are known to be killers, and worse than most drugs, they can result in the deaths of people who don’t even take them! They are implicated in virtually all the school shootings. That’s a lot of carnage.

Brintellix is an SSRI. Is there any reason to believe that it will produce less harm than other SSRIs? In fact, there is every reason to suspect the opposite.

By its developer’s own admission, no one knows what effects are produced by 5 of the 6 functions Brintellix was designed to cause. But we do know that the 6th function, serotonin/5-HT reuptake inhibition, is a killer. All of the other 5 functions interfere with normal brain activity—and the manufacturer admits that no one knows what those effects will be!

 What more do you need to know?

Read the full article here: http://gaia-health.com/gaia-blog/2013-10-04/why-new-antidepressant-brintellix-may-be-a-killer/

Sources:

  1. Takeda and Lundbeck announce FDA approval of Brintellix™ (vortioxetine) for treatment of adults with major depressive disorder. Lundbeck’s Brintellix press release.
  2. Antidepressant – vortioxetine. Manufacturer’s Chemist’s review of Brintellix.
  3. FDA approves new drug to treat major depressive disorder. FDA’s Brintellix approval announcement.
  4. Psychiatric drug-induced Chronic Brain Impairment (CBI): Implications for longterm treatment with psychiatric medicationInternational Journal of Risk and Safety in Medicine; DOI 10.3233/JRS-2011-0542.
  5. FDA approves a new antidepressant: BrintellixLos Angeles Times.
  6. Vortioxetine Adverse Effects; Medscape Reference.
  7. Vortioxetine (Lu AA21004) hydrobromide.
  8. Glutamate.
  9. Glutamate benefit and side effects, risk and danger.
  10. Vortioxetine: A New Antidepressant Choice in the United States

The Emperor’s New Drugs
Exploding the Antidepressant Myth
by Irving Kirsch Ph.D.

The Emperors New Drugs Book cover 202x300 Why New Antidepressant Brintellix May Be a Killer

Free Shipping Available!
More Info


0 commentsback to post

Other articlesgo to homepage

Former Staff Lead on Original Congressional Investigation Looking at Vaccine Injuries Speaks Out on CDC Fraud

Former Staff Lead on Original Congressional Investigation Looking at Vaccine Injuries Speaks Out on CDC Fraud

Pin It

Beth Clay is a unique contributor to the CDC whistleblower story. Clay was the staff lead on the original House Oversight Committee’s investigation looking into concerns about vaccine injuries in 1999. Working in Congress, she had a genuine desire to find the truth and find solutions regarding the rapidly increasing autism rates. What she found during her time in Congress, however, shocked her. So the recent revelations of Dr. Thompson, the CDC whistleblower, are not really “news” to her. Sadly, a government agency withholding information about a link between vaccines and autism is representative of the kind of fraud she too observed during her years in Congress.

CDC Director of Immunization Safety Admits Bias and Withholding Data Linking Vaccines to Autism

CDC Director of Immunization Safety Admits Bias and Withholding Data Linking Vaccines to Autism

Pin It

In what is quickly becoming one of the largest news stories in our lifetime, things are just getting worse for the CDC and their cover-up of data linking vaccines to autism.

Investigative journalist Sharyl Attkisson has posted a recorded phone call she just had with Dr. Frank DeStefano, the CDC Director of Immunization Safety. Dr. DeStefano was a co-author with CDC whistleblower Dr. William Thompson on a 2004 study that originally was put forward as research showing there was no link between vaccines and autism. Dr. Thompson has come forward and revealed that data was withheld from the public that showed an increased risk of autism in certain populations, specifically African American boys. The CDC has already made a public announcement admitting that they did withhold some data.

Dr. DeStefano has publicly stated that while he will reveal the data again, but that he is standing by the original study. A new audio recording of a conversation he just had with independent investigative reporter Sharyl Attkisson has just been posted on the Internet.

In this interview, Dr. DeStefano, who is not a whistle-blower, has come out with his own confession of bias and way of interpreting data so that it does not have to be shared with the public if it is not favorable with what they want to communicate regarding vaccines.

Dr. DeSefano and the CDC is being forced to answer questions like this (which unfortunately the mainstream media as of yet are NOT asking) because his co-author on the study, Dr. William Thompson, has hired one of the top whistleblower attorney’s in the nation so that he can come forward and reveal all the data the CDC has been hiding in regards to vaccines and autism.

60+ Natural ALS Cures the “Ice Washing” Campaign Isn’t Funding!

60+ Natural ALS Cures the “Ice Washing” Campaign Isn’t Funding!

Pin It

In a previous article we published on where funds donated to the ALS Association are being spent, we showed that a small percentage was actually spent on research, and even then only on pharmaceutical products. This has been our most popular story of the year so far.

Sayer Ji brings us a great review of over 60 natural cures that have published research on helping ALS. He also shows how some of the corporate sponsors of the ALS Association are pharmaceutical companies producing drugs that are linked to the cause of ALS!

MSM Marginalizes CDC Whistleblower Story on Vaccine-Autism Coverup

MSM Marginalizes CDC Whistleblower Story on Vaccine-Autism Coverup

Pin It

CNN was the first mainstream media (MSM) outlet to publish a story on the CDC whistleblower story linking vaccines to autism. Predictably, CNN marginalized this story on their website, and then posted a video from their TV network which said nothing about the CDC whistleblower Dr. William Thompson, but simply reiterated the MSM’s belief that all vaccines are safe and do not cause autism. They have posted a video that incorrectly represents facts regarding infant mortality and current whooping cough outbreaks that are occurring among fully vaccinated populations.

How can we trust anything CNN says on the vaccine issue if they misrepresent such basic facts regarding vaccines that are easily verified by 3rd party sources?

This story regarding the CDC cover-up has become too big for the MSM to ignore. They have to address it, but predictably they will continue to cover the story from their own belief system that the vaccine-autism debate is over, and that only one side of the debate should be heard. For those reporters that would dare to cover both sides of the debate, they will soon be without a career in MSM. So perhaps the American public needs to wake up and acknowledge this fact, and research the issue for themselves. A current senior scientist working for the CDC who has regrets over his participation in covering up data linking vaccines to autism is something worth taking some time to research.

CDC Whistleblower: Mercury in Vaccines Given to Pregnant Women Linked to Autism

CDC Whistleblower: Mercury in Vaccines Given to Pregnant Women Linked to Autism

Pin It

Today, the Autism Media Channel released a short video where CDC whistle-blower Dr. William Thompson states, in a phone call to Dr. Brian Hooker, that injecting mercury into pregnant women creates a “clear and present danger” to the unborn child. Thimerosal, a form of mercury used as a preservative in vaccines, was removed from most childhood vaccines a few years ago, but is still in the annual flu shot, which is recommended for pregnant women.

Dr. Thompson, in the video below, insists that this mercury in vaccines causes “tics” in children, and these tics are 4 times more prevalent in kids with autism. “Tics” are defined on the CDC website as: “Tics are sudden twitches, movements, or sounds that people do repeatedly. People who have tics cannot stop their body from doing these things. For example, a person with a motor tic might keep blinking over and over again. Or, a person with a vocal tic might make a grunting sound unwillingly.”

Watch the short 1 minute video.

read more


Get the news right in your inbox!